Effects of dietary calcium on intestinal non-haem iron absorption during weaning / by Peggy Efua Oti-Boateng.

Corrigenda tipped to title page.Includes bibliographical references (leaves 313-353).xxvii, 353 leaves : ill. (some col.) ; 30 cm.Investigates the iron status and dietary intakes in 6-24 month old children in Australia and Ghana and assesses the effects of dietary calcium on intestinal iron absorption. The true prevalence of non-anaemic iron deficiency (NAID) and iron deficiency anaemia (IDA) and dietary intakes in infants and toddlers from a broad socio-economic background were assessed by haematological and biochemical parameters, semi-quantitative diet recall and anthropometric measurements. The high prevalence of iron deficiency and anaemia found in Australian and Ghanaian children can be attributed to the low intake of bioavailable iron in weaning diets which are often ingested with large amounts of calcium. While calcium has been shown to inhibit the absorption of iron, its mechanism of interaction with iron absorption at the intestinal level is not known. The rat was used as an experimental model to investigate the effects of dietary calcium on duodenal iron uptake. The results indicate there is a critical period during weaning when the consumption of high dietary calcium with low iron can retard growth potential. Dietary calcium significantly inhibits non-haem iron absorption at the intracellular level by up-regulating villus enterocyte ferritin concentrations under iron deficiency conditions.Thesis (Ph.D.)--University of Adelaide, Dept. of Animal Science, 199