Association of aortic stenosis with platelet hyperaggregability and impaired responsiveness to nitric oxide
- Chirkov, Y.
- Holmes, A.
- Willoughby, S.
- Stewart, S.
- Horowitz, J.
Publication date
January 2002
DOI Publisher
Elsevier BV ISSN
0002-9149 Journal
The American Journal of CardiologyAbstract
Copyright © 2002 Excerpta Medica Inc. All rights reserved.In summary, the present study demonstrates that AS, irrespective of the presence and/or absence of CAD, is associated with platelet hyperaggregability and hyporesponsiveness to antiaggregatory effects of NO donor SNP. Treatment with the prophylactic antianginal agent perhexiline improves platelet responsiveness to NO.Yuliy Y. Chirkov, Andrew S. Holmes, Scott R. Willoughby, Simon Stewart, and John D. Horowit
Add to ORKG