Oophorectomy acutely increases calcium excretion in adult rats

Estrogen deficiency-induced bone loss is associated with complex changes in the calcium fluxes that constitute calcium balance. We studied the effects of oophorectomy on calcium balance and its components within the first 9 wk after the operation. Six-day calcium balance studies were performed on 30-wk-old female Sprague-Dawley rats before either sham operation or oophorectomy (oophx) and at 3-wk intervals for 9 wk postoperation. The rats were fed a diet containing 0.4g Ca/100 g diet and 0.3 g P/100 g diet throughout the study. The postoperative changes in calcium balance (P < 0.05) and net calcium absorption (P < 0.02) were negative in the oophx group compared with the ovary-intact group. The oophx group excreted more calcium via both the kidney (urine Ca, P < 0.05) and the gastrointestinal tract (endogenous fecal Ca, P < 0.05). The postoperation endogenous fecal calcium was higher at 3 wk postoophorectomy than at later times (P < 0.05). Oophorectomy did not affect true calcium absorption up to 9 wk postoophorectomy. Oophorectomy stimulates bone metabolism and our findings indicate that within the first 9 wk after oophorectomy, bone mineral loss is associated with a transient increase in the excretion of calcium by the gastrointestinal tract and the kidney