Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response

ObjectiveTo examine the anti-inflammatory activities of tea tree oil (TTO) in vivo.MethodsMice were sensitized to a chemical hapten, trinitrochlorobenzene, on their ventral skin and 7 days later challenged (or re-exposed) on their dorsal skin with the same hapten.ResultsTTO applied 30 min before or up to 7 h after to the same dorsal site as hapten challenge caused a significant reduction in skin swelling after 24 h. TTO reduced oedema but not the influx of inflammatory cells. This finding was supported by the inability of TTO to suppress TNFalpha-induced E-selectin expression by human umbilical vein endothelial cells. TTO did not suppress irritant- or ultraviolet B-induced oedema.ConclusionTopical TTO, specifically the TTO components, terpinen-4-ol and alpha-terpineol can regulate the oedema associated with the efferent phase of a contact hypersensitivity response.C. Brand, M. A. Grimbaldeston, J. R. Gamble, J. Drew, J. J. Finlay-Jones, P. H. Har