Humoral immune responses of Solomon Islanders to the merozoite surface antigen 2 (MSA2,MSP2) of Plasmodium falciparum show pronounced skewing towards antibodies of the IgG3 subclass
- Rzepczyk, C.
- Hale, K.
- Woodroffe, N.
- Bobogare, A.
- Csurhes, P.
- Ishii, A.
- Ferrante, A.
Publication date
January 1997
DOI Publisher
American Society for Microbiology Journal
Infection and ImmunityAbstract
The immunoglobulin G (IgG) subclass distribution of antibodies to merozoite surface antigen 2 of Plasmodium falciparum in Solomon Islanders showed marked skewing towards the IgG3 subclass. This was not observed with crude P. falciparum schizont antigen. IgG3 responses may be short-lived and require repeated restimulation for their maintenance. This may be provided by persistent infection (premunition) or new infections.Christine M. Rzepczyk, Kate Hale, Nick Woodroffe, Albino Bobogare, Peter Csurhes, Akira Ishii, And Antonio Ferrant
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