Cryptococcus症の研究 第III編 Cryptococcus症の感染経路についての検討

A study on experimental infection of cryptococcosis was carried out through oral, mucosal and subcutaneous inoculations. The results were as follows: 1. Encephalomeningitis was found only in the cases inoculated subcutaneously with mucin in the buccal region. In mice, 7 cases out of 8 (88%) and in rats, 5 cases out of 6 (83%) gave positive results. 2. Among these, meningitis was seen in 6 cases (86%) in mice and in 5 cases (100%) in rats, respectively. In these cases, histopathologic study revealed invasion of Cryptococcus neoformans in the lymphatic spaces of the brain. 3. Among the routes of infection of Cryptococcus neoformans the infection through the lymphatic vessel from the skin lesion of the head or the neck to the meninges proved to be efficient