Histochemical Studies on the Liver Tissue Iron Part 2 Histochemical Studies on the Liver Tissue Iron after the Administration of Liver Poison

Acute and chronic liver damage were caused by the liver poison of formic acid allyl and carbon tetrachloride on the grown up dog, and the distribution of liver tissue iron was observed, in comparison with the histological picture of the liver, blood easy split iron, serum iron and serum bilirubin value. And the result were as follows. 1. In the cases with acute toxication of formic acid allyl, the iron deposition was remarkable in the circumference of liver acinus i.e. marginal zone and Glisson's sack, and it was considerably found in the central zone and intermediate zone. 2. In the cases with chronic toxication of formic acid allyl, the iron deposition was localized in the circumference of liver acinus i.e. marginal zone and Glisson's sack. 3. In the cases with acute toxication of carbon tetrachloride, the iron deposition was remarkable in the central part of liver acinus. 4. In the cases with chronic toxication of carbon tetrachloride, the iron deposition was not only found in the central part of liver acinus, but it was also considerably found in the marginal zone and Glisson's sack of the circumference of liver acinus. 5. These iron deposition were the most remarkable in the stellate cells of local area and then in the liver cells, and the stellate cells had the picture thought the fullness of iron with the sewelling. This change was due to the hemolysis and local change produced by the administration of the above liver poisons, and it was different from the findings described in the first chapter. 6. The above tissue iron was triatomic region were not changed by the removed surface. Therefore, it was thought that the above tissue iron was the hemosiderin iron originated from the destruction of erythrocyte flowing out of the blood vessel