The Histological Differences of Balb/c Mice Uterine Glands in Gestation Period Which Given Kacip Fatimah (Labisia Pumila) Exposure with Graded Dose

Background : Rumput Fatimah (Labisia pumila), a traditional herb, used for accelerating the delivery process. There were controversies about the use of Labisia pumila's extract (eLP). Some articles stated there were cases of miscarriage, which is contrary to the previous research of Labisia pumila in experimental animal.Method : This was an experimental research with Post Only Control Group Test. The samples were 20 pregnant Balb/c mice randomly divided into 4 groups. The control group had given standard food and beverage. Every treatment group (P) administrated with eLP 13 mg/ml/mice/day. P1 administrated day 18 – 20 of pregnancy, P2 day 16 – 20 of pregnancy, P3 day 14 – 20 of pregnancy. Day 20, mice were terminated, the uterus was taken and was made histology slide.Result : Compared with control, P1 showed insignificant differences of uterine glands damage (p=0,213). P2 showed insignificant differences of uterine glands damage (p=0,050). P3 showed insignificant differences of uterine glands damage (p=0,070).Conclusion : There were insignificant differences of uterine glands histology in P compared both with the control group and the treatment group