Gambaran Histopatologi Lambung Tikus Wistar Yang Diberi Cabe Rawit (Capsicum Frutescens)

Background: Capsaicin is one of the active substantial that can be found in Chili pepper and one of the irritant for mammal that causing the burning sensation. The discomfort sensation in the gastric by capsaicin can be caused because the Transient receptor potential vanilloid-1 that can be found in gastric is stimulated.Objective: To demonstrate the gastric that was administered with Chili pepper.Method: The study conducted on Integrated Research Laboratory Faculty of Medicine Sam Ratulangi University Manado from October 2012 to January 2013. The study used 17 wistars, which divided to 5 groups and last to 7 days. This study was using Chili pepper in 45mg, 90mg, 135mg, and 180mg to study the histological changes of wistar rat's gastric.Results: The result showed that the administration of 180mg dose of Chili pepper did not cause a meaningful damage. The administration in 90mg of Chili pepper did cause a great damage with many inflammation signs occurring.Conclusions: The administration of Chili pepper in little to moderate dose causing a greater damage than the administration of Chili pepper in high dose