SIVagm Infection in Wild African Green Monkeys from South Africa: Epidemiology, Natural History, and Evolutionary Considerations
- Ma, D
- Jasinska, A
- Kristoff, J
- Grobler, JP
- Turner, T
- Jung, Y
- Schmitt, C
- Raehtz, K
- Feyertag, F
- Martinez Sosa, N
- Wijewardana, V
- Burke, DS
- Robertson, DL
- Tracy, R
- Pandrea, I
- Freimer, N
- Apetrei, C
DOIAbstract
Pathogenesis studies of SIV infection have not been performed to date in wild monkeys due to difficulty in collecting and storing samples on site and the lack of analytical reagents covering the extensive SIV diversity. We performed a large scale study of molecular epidemiology and natural history of SIVagm infection in 225 free-ranging AGMs from multiple locations in South Africa. SIV prevalence (established by sequencing pol, env, and gag) varied dramatically between infant/juvenile (7%) and adult animals (68%) (p<0.0001), and between adult females (78%) and males (57%). Phylogenetic analyses revealed an extensive genetic diversity, including frequent recombination events. Some AGMs harbored epidemiologically linked viruses. Viruses infec...
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