Identification, replication, and fine-mapping of loci associated with adult height in individuals of African ancestry
- N'Diaye, A
- Chen, GK
- Palmer, CD
- Ge, B
- Tayo, B
- Mathias, RA
- Ding, J
- Nalls, MA
- Adeyemo, A
- Adoue, V
- Ambrosone, CB
- Atwood, L
- Bandera, EV
- Becker, LC
- Berndt, SI
- Bernstein, L
- Blot, WJ
- Boerwinkle, E
- Britton, A
- Casey, G
- Chanock, SJ
- Demerath, E
- Deming, SL
- Diver, WR
- Fox, C
- Harris, TB
- Hernandez, DG
- Hu, JJ
- Ingles, SA
- John, EM
- Johnson, C
- Keating, B
- Kittles, RA
- Kolonel, LN
- Kritchevsky, SB
- Marchand, L
- Lohman, K
- Liu, J
- Millikan, RC
- Murphy, A
- Musani, S
- Neslund-Dudas, C
- North, KE
- Nyante, S
- Ogunniyi, A
- Ostrander, EA
- Papanicolaou, G
- Patel, S
- Pettaway, CA
- Press, MF
- Redline, S
- Rodriguez-Gil, JL
- Rotimi, C
- Rybicki, BA
- Salako, B
- Schreiner, PJ
- Signorello, LB
- Singleton, AB
- Stanford, JL
- Stram, AH
- Stram, DO
- Strom, SS
- Suktitipat, B
- Thun, MJ
- Witte, JS
- Yanek, LR
- Ziegler, RG
- Zheng, W
- Zhu, X
- Zmuda, JM
- Zonderman, AB
- Evans, MK
- Liu, Y
- Becker, DM
- Cooper, RS
- Pastinen, T
- Henderson, BE
- Hirschhorn, JN
- Lettre, G
- Haiman, CA
DOIAbstract
Adult height is a classic polygenic trait of high heritability (h 2 ~0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ~10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10 -12 and 2p14-rs4315565, P = 1.2×10 -8). As a group, height asso...
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