Role of estrogens and epidermal growth factor in hepatocellular carcinoma (HCC)
- Francavilla, A
- Panella, C
- Amoruso, A
- Giangaspero, A
- Gennari, L
- Mazzaferro, V
- Colella, G
- Van Thiel, DH
- Starzl, TE
Publication date
September 1991
DOI Publisher
Springer Science and Business Media LLCAbstract
Estrogen (E) and epidermal growth factors (EGF) receptors were assayed in the liver of nine patients with hepatocellular carcinoma (HCC). Total E and nuclear E receptors were decreased significantly in neoplastic tissue as compared to the levels found in surrounding nonneoplastic tissue. The EGF receptor was decreased also in neoplastic tissue. On the basis of binding data, a decrease in the number but not in affinity of both the E and EGF receptors was found. © 1991 Plenum Publishing Corporation
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