The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to caspase-8, blocks downstream signaling and thus contributes to viral fitness in macrophages and in vivo. Here we show a direct link between the inability of mutants lacking the M36 gene (ΔM36) to inhibit apoptosis, poor viral growth in macrophage cell cultures and viral in vivo fitness and virulence. ΔM36 grew poorly in RAG1 knockout mice and in RAG/IL-2-receptor common gamma chain double knockout mice (RAGγC(-/-)), but the depletion of macrophages in either mouse strain rescued the growth of Δ...
Cytomegalovirus (CMV) has developed diverse tactics to elude the host immune response and guarantee ...
The receptor-like protein tyrosine phosphatase CD45 is expressed on the surface of cells of hematopo...
<div><p>TNF-related apoptosis inducing ligand (TRAIL) death receptors (DR) regulate apoptosis and in...
The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus...
<div><p>The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomeg...
Apoptosis is an important defense mechanism mounted by the immune system to control virus replicatio...
Apoptosis is an important defensemechanismmounted by the immune systemto control virus replication....
AbstractHuman cytomegalovirus (CMV) genes UL36 and UL37 encode viral inhibitor of caspase-8-induced ...
Programmed cell death pathways eliminate infected cells and regulate infection-associated inflammati...
Apoptosis induction is an important host defense mechanism to control viral infection, which is anta...
Viral infection activates cellular antiviral defenses including programmed cell death (PCD). Many vi...
Receptors of the signalling lymphocyte-activation molecules (SLAM) family are involved in the functi...
Viruses have evolved various strategies to prevent premature apoptosis of infected host cells. Some ...
Apoptosis of infected cells can limit virus replication and serves as an innate defense mechanism ag...
Viral subversion of apoptosis regulation plays an important role in the outcome of host/virus intera...
Cytomegalovirus (CMV) has developed diverse tactics to elude the host immune response and guarantee ...
The receptor-like protein tyrosine phosphatase CD45 is expressed on the surface of cells of hematopo...
<div><p>TNF-related apoptosis inducing ligand (TRAIL) death receptors (DR) regulate apoptosis and in...
The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus...
<div><p>The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomeg...
Apoptosis is an important defense mechanism mounted by the immune system to control virus replicatio...
Apoptosis is an important defensemechanismmounted by the immune systemto control virus replication....
AbstractHuman cytomegalovirus (CMV) genes UL36 and UL37 encode viral inhibitor of caspase-8-induced ...
Programmed cell death pathways eliminate infected cells and regulate infection-associated inflammati...
Apoptosis induction is an important host defense mechanism to control viral infection, which is anta...
Viral infection activates cellular antiviral defenses including programmed cell death (PCD). Many vi...
Receptors of the signalling lymphocyte-activation molecules (SLAM) family are involved in the functi...
Viruses have evolved various strategies to prevent premature apoptosis of infected host cells. Some ...
Apoptosis of infected cells can limit virus replication and serves as an innate defense mechanism ag...
Viral subversion of apoptosis regulation plays an important role in the outcome of host/virus intera...
Cytomegalovirus (CMV) has developed diverse tactics to elude the host immune response and guarantee ...
The receptor-like protein tyrosine phosphatase CD45 is expressed on the surface of cells of hematopo...
<div><p>TNF-related apoptosis inducing ligand (TRAIL) death receptors (DR) regulate apoptosis and in...