The effect of binder properties on torque curves, granule growth kinetics, wet mass consistency and dry granule strength has been investigated in this study. Granulation runs have been performed on a fine cohesive microcrystalline cellulose powder (Avicel 105, d50 = 20 μm) in two types of laboratory high shear mixers: a Mi-Pro high shear mixer using a 1.9 L bowl and a 6 L Diosna high shear mixer. Binders used included ultra-pure water and solutions of varying concentrations of PVP and HPMC allowing us to cover different values for parameters like viscosity and work of adhesion. Torque curves recorded during granulation are found to allow good control of the process. Optimum liquid requirement for granulation has been found to vary with bind...
Processing of granular material often requires mixing steps in order to blend cohesive powders, dist...
Purpose. To investigate the background of the observed relationship between measured torque and gran...
Granule consolidation was studied experimentally using a 0.3 m diameter laboratory granulation drum ...
The effect of the main means of agitation in a high shear mixer has been investigated in this study....
Abstract. The wet granulation process is sensitive to changes in product properties and process vari...
The wet granulation process is sensitive to changes in product properties and process variables. The...
The evolution of a high shear wet granulation process (HSWG) depends on wet masses properties such a...
Paper presented at the 7th International Symposium on Agglomeration, held in Albi, France from 29 t...
MastersOver 50 years of research in granulation technology, whoever more researches are required to ...
The aim of this study was to investigate the applicability of the regime map approach proposed by Li...
The purpose of the first part of the study was to determine the end point for granulations with cont...
An alternative procedure for achieving formulation design in a high-shear wet granulation process ha...
A Hobart mixer was instrumented with a slip ring torque sensor, signals were amplified and the outpu...
The effect of a wide variety of binders on the quality of granules produced via continuous twin scre...
This study is dedicated to the understanding of the wet granulation process in high shear mixers. A ...
Processing of granular material often requires mixing steps in order to blend cohesive powders, dist...
Purpose. To investigate the background of the observed relationship between measured torque and gran...
Granule consolidation was studied experimentally using a 0.3 m diameter laboratory granulation drum ...
The effect of the main means of agitation in a high shear mixer has been investigated in this study....
Abstract. The wet granulation process is sensitive to changes in product properties and process vari...
The wet granulation process is sensitive to changes in product properties and process variables. The...
The evolution of a high shear wet granulation process (HSWG) depends on wet masses properties such a...
Paper presented at the 7th International Symposium on Agglomeration, held in Albi, France from 29 t...
MastersOver 50 years of research in granulation technology, whoever more researches are required to ...
The aim of this study was to investigate the applicability of the regime map approach proposed by Li...
The purpose of the first part of the study was to determine the end point for granulations with cont...
An alternative procedure for achieving formulation design in a high-shear wet granulation process ha...
A Hobart mixer was instrumented with a slip ring torque sensor, signals were amplified and the outpu...
The effect of a wide variety of binders on the quality of granules produced via continuous twin scre...
This study is dedicated to the understanding of the wet granulation process in high shear mixers. A ...
Processing of granular material often requires mixing steps in order to blend cohesive powders, dist...
Purpose. To investigate the background of the observed relationship between measured torque and gran...
Granule consolidation was studied experimentally using a 0.3 m diameter laboratory granulation drum ...