Clinical neuroimaging in the preterm infant: Diagnosis and prognosis
- Manuel Hinojosa-Rodríguez
- Thalía Harmony
- Cristina Carrillo-Prado
- John Darrell Van Horn
- Andrei Irimia
- Carinna Torgerson
- Zachary Jacokes
DOIAbstract
Perinatal care advances emerging over the past twenty years have helped to diminish the mortality and severe neurological morbidity of extremely and very preterm neonates (e.g., cystic Periventricular Leukomalacia [c-PVL] and Germinal Matrix Hemorrhage – Intraventricular Hemorrhage [GMH-IVH grade 3–4/4]; 22 to <32weeks of gestational age, GA). However, motor and/or cognitive disabilities associated with mild-to-moderate white and gray matter injury are frequently present in this population (e.g., non-cystic Periventricular Leukomalacia [non-cystic PVL], neuronal–axonal injury and GMH-IVH grade 1–2/4). Brain research studies using magnetic resonance imaging (MRI) report that 50% to 80% of extremely and very preterm neonates have diffuse whit...
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