Summary: Although all human tissues carry out common processes, tissues are distinguished by gene expression patterns, implying that distinct regulatory programs control tissue specificity. In this study, we investigate gene expression and regulation across 38 tissues profiled in the Genotype-Tissue Expression project. We find that network edges (transcription factor to target gene connections) have higher tissue specificity than network nodes (genes) and that regulating nodes (transcription factors) are less likely to be expressed in a tissue-specific manner as compared to their targets (genes). Gene set enrichment analysis of network targeting also indicates that the regulation of tissue-specific function is largely independent of transcr...
Gene expression is a tightly controlled process in all cells and at all stages of life. Expressing ...
It is known that genetic variants can affect gene expression, but it is not yet completely clear thr...
Background: Development and maintenance of the identity of tissues is of central importance for mult...
Abstract Background Tissue gene expression is generally regulated by multiple transcription factors ...
To understand the regulation of tissue-specific gene expression, the GTEx Consortium gen-erated RNA-...
<div><p>To understand the regulation of tissue-specific gene expression, the GTEx Consortium generat...
Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We de...
Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We de...
Background: Predicting molecular responses in human by extrapolating results from model organisms re...
Construction and analyses of tissue specific networks is crucial to unveil the function and organiza...
<p>a) Tissue-specific transcription factors (circled in blue) have higher expression levels (green) ...
BACKGROUND: Development and maintenance of the identity of tissues is of central importance for mult...
It is known that genetic variants can affect gene expression, but it is not yet completely clear thr...
Background: Transcriptional networks of higher eukaryotes are difficult to obtain. Available experim...
© 2017 Saha et al. Gene co-expression networks capture biologically important patterns in gene expre...
Gene expression is a tightly controlled process in all cells and at all stages of life. Expressing ...
It is known that genetic variants can affect gene expression, but it is not yet completely clear thr...
Background: Development and maintenance of the identity of tissues is of central importance for mult...
Abstract Background Tissue gene expression is generally regulated by multiple transcription factors ...
To understand the regulation of tissue-specific gene expression, the GTEx Consortium gen-erated RNA-...
<div><p>To understand the regulation of tissue-specific gene expression, the GTEx Consortium generat...
Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We de...
Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We de...
Background: Predicting molecular responses in human by extrapolating results from model organisms re...
Construction and analyses of tissue specific networks is crucial to unveil the function and organiza...
<p>a) Tissue-specific transcription factors (circled in blue) have higher expression levels (green) ...
BACKGROUND: Development and maintenance of the identity of tissues is of central importance for mult...
It is known that genetic variants can affect gene expression, but it is not yet completely clear thr...
Background: Transcriptional networks of higher eukaryotes are difficult to obtain. Available experim...
© 2017 Saha et al. Gene co-expression networks capture biologically important patterns in gene expre...
Gene expression is a tightly controlled process in all cells and at all stages of life. Expressing ...
It is known that genetic variants can affect gene expression, but it is not yet completely clear thr...
Background: Development and maintenance of the identity of tissues is of central importance for mult...