While the synthesis and use of new chemical compounds is at an all-time high, the study of their potential impact on human health is quickly falling behind, and new methods are needed to assess their impact. We chose to examine the effects of two common environmental chemicals, the insect repellent N,N-diethyl-m-toluamide (DEET) and the insecticide fluocyanobenpyrazole (fipronil), on transcript levels of long non-protein coding RNAs (lncRNAs) in primary human hepatocytes using a global RNA-Seq approach. While lncRNAs are believed to play a critical role in numerous important biological processes, many still remain uncharacterized, and their functions and modes of action remain largely unclear, especially in relation to environmental chemica...
Background and Aim: The worldwide prevalence of alcoholic liver disease (ALD) due to escalating alco...
Long non-coding RNAs (lncRNAs) are comprised of RNA transcripts exceeding 200 nucleotides in length ...
In recent years, accumulating evidence supports the importance of microRNAs in liver physiology and ...
While the synthesis and use of new chemical compounds is at an all-time high, the study of their pot...
Xenobiotic exposure dysregulates hundreds of protein-coding genes in mammalian liver, impacting many...
Hepatic cytochrome P450 (P450) mediated metabolism, which includes the metabolism of both endogenous...
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldw...
Perturbation of biological networks is often observed during exposure to xenobiotics, and the identi...
Genomic analysis has found that the transcriptome in both humans and Drosophila melanogaster feature...
Gut microbiome communicates with the host liver to modify hepatic xenobiotic biotransformation and n...
Long non-coding RNAs (lncRNAs) are key regulators of gene expression, playing crucial roles in biolo...
Long non-coding RNAs (lncRNAs) have attracted considerable research interest, but so far no data are...
In this study, we focused on two biological products as ideal tools for toxicological assessment: lo...
Industrial, agricultural, and pharmaceutical requirements drive the development of a plethora of new...
Introduction and aim. Autophagy and its regulated pathways participate in many important cellular ph...
Background and Aim: The worldwide prevalence of alcoholic liver disease (ALD) due to escalating alco...
Long non-coding RNAs (lncRNAs) are comprised of RNA transcripts exceeding 200 nucleotides in length ...
In recent years, accumulating evidence supports the importance of microRNAs in liver physiology and ...
While the synthesis and use of new chemical compounds is at an all-time high, the study of their pot...
Xenobiotic exposure dysregulates hundreds of protein-coding genes in mammalian liver, impacting many...
Hepatic cytochrome P450 (P450) mediated metabolism, which includes the metabolism of both endogenous...
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldw...
Perturbation of biological networks is often observed during exposure to xenobiotics, and the identi...
Genomic analysis has found that the transcriptome in both humans and Drosophila melanogaster feature...
Gut microbiome communicates with the host liver to modify hepatic xenobiotic biotransformation and n...
Long non-coding RNAs (lncRNAs) are key regulators of gene expression, playing crucial roles in biolo...
Long non-coding RNAs (lncRNAs) have attracted considerable research interest, but so far no data are...
In this study, we focused on two biological products as ideal tools for toxicological assessment: lo...
Industrial, agricultural, and pharmaceutical requirements drive the development of a plethora of new...
Introduction and aim. Autophagy and its regulated pathways participate in many important cellular ph...
Background and Aim: The worldwide prevalence of alcoholic liver disease (ALD) due to escalating alco...
Long non-coding RNAs (lncRNAs) are comprised of RNA transcripts exceeding 200 nucleotides in length ...
In recent years, accumulating evidence supports the importance of microRNAs in liver physiology and ...