Cyclodextrins are a family of cyclic oligosaccharides with widespread usage in medicine, industry and basic sciences owing to their ability to solubilize and stabilize guest compounds. In medicine, cyclodextrins primarily act as a complexing vehicle and consequently serve as powerful drug delivery agents. Recently, uncomplexed cyclodextrins have emerged as potent therapeutic compounds in their own right, based on their ability to sequester and mobilize cellular lipids. In particular, 2-hydroxypropyl-β-cyclodextrin (HPβCD) has garnered attention because of its cholesterol chelating properties, which appear to treat a rare neurodegenerative disorder and to promote atherosclerosis regression related to stroke and heart disease. Despite the pot...
Sensorineural hearing loss (SNHL) is a prevalent neurodegenerative disorder often involving permanen...
Niemann‐Pick disease type C (NPC) is a severe disorder that is characterized by intracellular transp...
[Background] The blood-labyrinth barrier (BLB) separates the inner ear from the circulation and is c...
<div><p>Cyclodextrins are sugar compounds that are increasingly finding medicinal uses due to their ...
Cyclodextrins are sugar compounds that are increasingly finding medicinal uses due to their ability ...
2-Hydroxypropyl-Beta-Cyclodextrin (HPβCD) can be used to treat Niemann-Pick type C disease, Alzheime...
Abstract Niemann-Pick Type C1 (NPC1) disease is a fatal neurovisceral disorder caused by dysfunction...
Niemann-Pick type C1 disease (NPC1) is a fatal genetic disorder caused by impaired intracellular cho...
This paper reviews intriguing recent findings on the mechanisms of drug induced hearing loss caused ...
Clinical ototoxicity—permanent hearing loss caused by medications—is estimated to affect millions of...
Hearing loss is a significant health problem that can result from a variety of exogenous insults tha...
Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic...
Niemann Pick type C disease (NPC) is a rare lysosomal storage disorder characterized by a progressiv...
This review introduces the pathology of aminoglycoside antibiotic and the cisplatin chemotherapy cla...
Cisplatin is a widely used chemotherapeutic drug for the treatment of solid tumors. However, the dru...
Sensorineural hearing loss (SNHL) is a prevalent neurodegenerative disorder often involving permanen...
Niemann‐Pick disease type C (NPC) is a severe disorder that is characterized by intracellular transp...
[Background] The blood-labyrinth barrier (BLB) separates the inner ear from the circulation and is c...
<div><p>Cyclodextrins are sugar compounds that are increasingly finding medicinal uses due to their ...
Cyclodextrins are sugar compounds that are increasingly finding medicinal uses due to their ability ...
2-Hydroxypropyl-Beta-Cyclodextrin (HPβCD) can be used to treat Niemann-Pick type C disease, Alzheime...
Abstract Niemann-Pick Type C1 (NPC1) disease is a fatal neurovisceral disorder caused by dysfunction...
Niemann-Pick type C1 disease (NPC1) is a fatal genetic disorder caused by impaired intracellular cho...
This paper reviews intriguing recent findings on the mechanisms of drug induced hearing loss caused ...
Clinical ototoxicity—permanent hearing loss caused by medications—is estimated to affect millions of...
Hearing loss is a significant health problem that can result from a variety of exogenous insults tha...
Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic...
Niemann Pick type C disease (NPC) is a rare lysosomal storage disorder characterized by a progressiv...
This review introduces the pathology of aminoglycoside antibiotic and the cisplatin chemotherapy cla...
Cisplatin is a widely used chemotherapeutic drug for the treatment of solid tumors. However, the dru...
Sensorineural hearing loss (SNHL) is a prevalent neurodegenerative disorder often involving permanen...
Niemann‐Pick disease type C (NPC) is a severe disorder that is characterized by intracellular transp...
[Background] The blood-labyrinth barrier (BLB) separates the inner ear from the circulation and is c...