Effect of women's age on embryo morphology, cleavage rate and competence-A multicenter cohort study.
- Marie Louise Grøndahl
- Sofie Lindgren Christiansen
- Ulrik Schiøler Kesmodel
- Inge Errebo Agerholm
- Josephine Gabriela Lemmen
- Peter Lundstrøm
- Jeanette Bogstad
- Morten Raaschou-Jensen
- Steen Ladelund
DOIAbstract
This multicenter cohort study on embryo assessment and outcome data from 11,744 IVF/ICSI cycles with 104,830 oocytes and 42,074 embryos, presents the effect of women's age on oocyte, zygote, embryo morphology and cleavage parameters, as well as cycle outcome measures corrected for confounding factors as center, partner's age and referral diagnosis. Cycle outcome data confirmed the well-known effect of women's age. Oocyte nuclear maturation and proportion of 2 pro-nuclear (2PN) zygotes were not affected by age, while a significant increase in 3PN zygotes was observed in both IVF and ICSI (p<0.0001) with increasing age. Maternal age had no effect on cleavage parameters or on the morphology of the embryo day 2 post insemination. Interestingly,...
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