Allogeneic transplantation (Tx) of induced pluripotent stem cells (iPSCs) is a promising tissue regeneration therapy. However, this inevitably induces macrophage-mediated immune response against the graft, limiting its therapeutic efficacy. Monitoring the magnitude of the immune response using imaging tools would be useful for prolonging graft survival and increasing the therapy longevity. Minimally invasive quantitative detection of activated macrophages by medical imaging technologies such as positron emission tomography (PET) imaging targets translocator protein (TSPO), which is highly expressed on mitochondrial membrane, especially in activated macrophage. N,N-diethyl-2-[4-(2-fluoroethoxy) phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3...
UnlabelledThe proliferation and trafficking of T lymphocytes in immune responses are crucial events ...
<div><p>Whether differentiation of induced pluripotent stem cells (iPSCs) in ischemic myocardium enh...
The immune system plays a crucial role in many diseases. Activation or suppression of immunity is of...
Monitoring of cell transplantation in vivo is crucial to understanding how the progeny of stem cells...
BackgroundMacrophages represent a critical cell type in host defense, development and homeostasis. T...
BACKGROUND: Current immunosuppressive therapy after heart transplantation either generally suppresse...
In vivo cell tracking by MRI can provide means to observe biological processes and monitor cell ther...
There is a need for in vivo monitoring of cell engraftment and survival after cardiac cell transplan...
Molecular imaging holds great promise for the in vivo study of cell therapy. Our hypothesis was that...
Whether differentiation of induced pluripotent stem cells (iPSCs) in ischemic myocardium enhances th...
A major barrier to successful use of allogeneic hematopoietic cell transplantation is acute graft-ve...
OBJECTIVES:Myocardial infarction (MI) causes significant loss of cardiomyocytes, myocardial tissue d...
Multiple diseases including blood disorders, autoimmunity, infections, and cancer result from defect...
PURPOSE: Non-invasive techniques to monitor the survival and migration of transplanted stem cells in...
The measurement of immunological reactivity to donor antigens in transplant recipients is likely to ...
UnlabelledThe proliferation and trafficking of T lymphocytes in immune responses are crucial events ...
<div><p>Whether differentiation of induced pluripotent stem cells (iPSCs) in ischemic myocardium enh...
The immune system plays a crucial role in many diseases. Activation or suppression of immunity is of...
Monitoring of cell transplantation in vivo is crucial to understanding how the progeny of stem cells...
BackgroundMacrophages represent a critical cell type in host defense, development and homeostasis. T...
BACKGROUND: Current immunosuppressive therapy after heart transplantation either generally suppresse...
In vivo cell tracking by MRI can provide means to observe biological processes and monitor cell ther...
There is a need for in vivo monitoring of cell engraftment and survival after cardiac cell transplan...
Molecular imaging holds great promise for the in vivo study of cell therapy. Our hypothesis was that...
Whether differentiation of induced pluripotent stem cells (iPSCs) in ischemic myocardium enhances th...
A major barrier to successful use of allogeneic hematopoietic cell transplantation is acute graft-ve...
OBJECTIVES:Myocardial infarction (MI) causes significant loss of cardiomyocytes, myocardial tissue d...
Multiple diseases including blood disorders, autoimmunity, infections, and cancer result from defect...
PURPOSE: Non-invasive techniques to monitor the survival and migration of transplanted stem cells in...
The measurement of immunological reactivity to donor antigens in transplant recipients is likely to ...
UnlabelledThe proliferation and trafficking of T lymphocytes in immune responses are crucial events ...
<div><p>Whether differentiation of induced pluripotent stem cells (iPSCs) in ischemic myocardium enh...
The immune system plays a crucial role in many diseases. Activation or suppression of immunity is of...