Cardioprotection of dexrazoxane (DZR) against doxorubicin (DOX)-induced cardiotoxicity is contentious and the indicator is controversial. A pairwise comparative metabolomics approach was used to delineate the potential metabolic processes in the present study. Ninety-six BALB/c mice were randomly divided into two supergroups: tumor and control groups. Each supergroup was divided into control, DOX, DZR, and DOX plus DZR treatment groups. DOX treatment resulted in a steady increase in 5-hydroxylysine, 2-hydroxybutyrate, 2-oxoglutarate, 3-hydroxybutyrate, and decrease in glucose, glutamate, cysteine, acetone, methionine, asparate, isoleucine, and glycylproline.DZR treatment led to increase in lactate, 3-hydroxybutyrate, glutamate, alanine, and...
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Science...
Dexrazoxane (DEX), a bisdioxopiperazine derivative, is the only clinically used drug effective again...
1. Dexrazoxane (DXR, ICRF-187) has been shown both in animal studies and clinical trials to provide ...
BACKGROUND: The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, b...
The cost of dexrazoxane, a drug used to provide protection from doxorubicin-induced cardiotoxicity, ...
Several front-line chemotherapeutics cause mitochondria-derived, oxidative stress-mediated cardiotox...
<div><p>Several front-line chemotherapeutics cause mitochondria-derived, oxidative stress-mediated c...
The long-lasting protective effect of dexrazoxane (ADR-529) against doxorubicin- and epirubicin-indu...
Doxorubicin-induced cardiomyopathy (DOX-CM) is a severe complication of doxorubicin (DOX) chemothera...
Dose-dependent cardiotoxicity is the leading adverse reaction seen in cancer patients treated with d...
<div><p>Doxorubicin-induced cardiomyopathy (DOX-CM) is a severe complication of doxorubicin (DOX) ch...
- CARDIOTOXICITY OF ANTHRACYCLINE ANTINEOPLASTIC DRUGS AND POSSIBILITIES OF PHARMACOLOGICAL CARDIOPR...
BACKGROUND: Doxorubicin (DOX) is one of the most potent antitumor agents available; however, its cli...
- CARDIOTOXICITY OF ANTHRACYCLINE ANTINEOPLASTIC DRUGS AND POSSIBILITIES OF PHARMACOLOGICAL CARDIOPR...
Dexrazoxane was found effective in reducing doxorubicin cardiotoxicity when given at a dose ratio (d...
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Science...
Dexrazoxane (DEX), a bisdioxopiperazine derivative, is the only clinically used drug effective again...
1. Dexrazoxane (DXR, ICRF-187) has been shown both in animal studies and clinical trials to provide ...
BACKGROUND: The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, b...
The cost of dexrazoxane, a drug used to provide protection from doxorubicin-induced cardiotoxicity, ...
Several front-line chemotherapeutics cause mitochondria-derived, oxidative stress-mediated cardiotox...
<div><p>Several front-line chemotherapeutics cause mitochondria-derived, oxidative stress-mediated c...
The long-lasting protective effect of dexrazoxane (ADR-529) against doxorubicin- and epirubicin-indu...
Doxorubicin-induced cardiomyopathy (DOX-CM) is a severe complication of doxorubicin (DOX) chemothera...
Dose-dependent cardiotoxicity is the leading adverse reaction seen in cancer patients treated with d...
<div><p>Doxorubicin-induced cardiomyopathy (DOX-CM) is a severe complication of doxorubicin (DOX) ch...
- CARDIOTOXICITY OF ANTHRACYCLINE ANTINEOPLASTIC DRUGS AND POSSIBILITIES OF PHARMACOLOGICAL CARDIOPR...
BACKGROUND: Doxorubicin (DOX) is one of the most potent antitumor agents available; however, its cli...
- CARDIOTOXICITY OF ANTHRACYCLINE ANTINEOPLASTIC DRUGS AND POSSIBILITIES OF PHARMACOLOGICAL CARDIOPR...
Dexrazoxane was found effective in reducing doxorubicin cardiotoxicity when given at a dose ratio (d...
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Science...
Dexrazoxane (DEX), a bisdioxopiperazine derivative, is the only clinically used drug effective again...
1. Dexrazoxane (DXR, ICRF-187) has been shown both in animal studies and clinical trials to provide ...