Argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis, is expressed in many types of human malignancies. Recent studies showed that ASS1 may have tumor suppressor function and that ASS1 deficiency is associated with clinical aggressiveness in nasopharyngeal carcinoma, myxofibrosarcomas and bladder cancer. The goal of this study was to evaluate the prognostic impact of ASS1 expression in patients with pancreatic ductal adenocarcinoma (PDAC). Our study included two independent cohorts: untreated cohort, which was comprised of 135 patients with PDAC who underwent pancreatoduodenectomy (PD) without pre-operative neoadjuvant therapy, and treated cohort, which was comprised of 122 patients with PDAC who have co...
Many cancers lack functional expression of the enzyme argininosuccinate synthetase 1 (ASS1) that is ...
Importance: Preclinical studies show that arginine deprivation is synthetically lethal in argininosu...
Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epig...
<p><b>Representative micrographs showing ASS1 expression in normal pancreas (A) and chronic pancreat...
Arginine (Arg) deprivation is a promising therapeutic approach for tumors with low argininosuccinate...
Arginine, a semi-essential amino acid in humans, is critical for the growth of human cancers, partic...
[[abstract]]Background: Argininosuccinate synthase 1 (ASS1), catalyzing the penultimate step of the ...
Targeted therapies have yet to have significant impact on the survival of patients with bladder canc...
[[abstract]]SummaryObjectives Arginine is a nonessential amino acid which can regulate tumor growth....
Argininosuccinate synthase (ASS1) downregulation in different tumors has been shown to support cell ...
[[abstract]]Targeted therapies have yet to have significant impact on the survival of patients with ...
Background and Aim Arginine is a nonessential amino acid for humans and mice because it can be synth...
Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tu...
Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis. ASS1 expr...
[[abstract]]The risk stratification and final outcomes in patients with nasopharyngeal carcinomas (N...
Many cancers lack functional expression of the enzyme argininosuccinate synthetase 1 (ASS1) that is ...
Importance: Preclinical studies show that arginine deprivation is synthetically lethal in argininosu...
Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epig...
<p><b>Representative micrographs showing ASS1 expression in normal pancreas (A) and chronic pancreat...
Arginine (Arg) deprivation is a promising therapeutic approach for tumors with low argininosuccinate...
Arginine, a semi-essential amino acid in humans, is critical for the growth of human cancers, partic...
[[abstract]]Background: Argininosuccinate synthase 1 (ASS1), catalyzing the penultimate step of the ...
Targeted therapies have yet to have significant impact on the survival of patients with bladder canc...
[[abstract]]SummaryObjectives Arginine is a nonessential amino acid which can regulate tumor growth....
Argininosuccinate synthase (ASS1) downregulation in different tumors has been shown to support cell ...
[[abstract]]Targeted therapies have yet to have significant impact on the survival of patients with ...
Background and Aim Arginine is a nonessential amino acid for humans and mice because it can be synth...
Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tu...
Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis. ASS1 expr...
[[abstract]]The risk stratification and final outcomes in patients with nasopharyngeal carcinomas (N...
Many cancers lack functional expression of the enzyme argininosuccinate synthetase 1 (ASS1) that is ...
Importance: Preclinical studies show that arginine deprivation is synthetically lethal in argininosu...
Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epig...