Prediction of Small for Gestational Age Infants in Healthy Nulliparous Women Using Clinical and Ultrasound Risk Factors Combined with Early Pregnancy Biomarkers.

Lesley M E McCowan
John M D Thompson
Rennae S Taylor
Philip N Baker
Robyn A North
Lucilla Poston
Claire T Roberts
Nigel A B Simpson
James J Walker
Jenny Myers
Louise C Kenny
SCOPE consortium

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Publication date

January 2017

DOI

10.1371/journal.pone.0169311

Publisher

Public Library of Science (PLoS)

Journal

PLoS ONE

Abstract

Most small for gestational age pregnancies are unrecognised before birth, resulting in substantial avoidable perinatal mortality and morbidity. Our objective was to develop multivariable prediction models for small for gestational age combining clinical risk factors and biomarkers at 15±1 weeks' with ultrasound parameters at 20±1 weeks' gestation.Data from 5606 participants in the Screening for Pregnancy Endpoints (SCOPE) cohort study were divided into Training (n = 3735) and Validation datasets (n = 1871). The primary outcomes were All-SGA (small for gestational age with birthweight <10th customised centile), Normotensive-SGA (small for gestational age with a normotensive mother) and Hypertensive-SGA (small for gestational age with an hype...