Falcarindiol (FAD) is a natural polyyne have been found in many food and dietary plants. It has been found to have various beneficial biological activities. In this study, we demonstrated its anticancer function and mechanism in breast cancer cells. We found that FAD preferentially induces cell death in breast cancer cells. FAD-induced cell death is caspase-dependent. However, FAD induces autophagy to contribute to the cell death. Blocking autophagy by either chemical inhibitors or genetic knockout of autophagy signaling component inhibits FAD-induced cell death. We further found that FAD-induced cell death is mediated by the induction of endoplasmic reticulum stress. We also identified that FAD has synergistic effect with approved cancer d...
Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional n...
Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional n...
Oxidative stress created by environmental toxicants activates several signaling pathways. Autophagy ...
<p>(A) Cell death of MDA-MB-231 cells treated with 6 uM of FAD with or without 100 uM of Z-VAD-fmk (...
Autophagy is a homeostatic process that is highly conserved across different types of mammalian cell...
Background: Breast cancer is accounted as the fifth leading cause of mortality among the other can-c...
Autophagy is a vital basic phenomenon that widely exists in eukaryotic cells. As one type of program...
Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer N H...
Autophagy is linked to multiple cancer-related signaling pathways, and represents a defense mechanis...
Autophagy is linked to multiple cancer-related signaling pathways, and represents a defense mechanis...
Autophagy is linked to multiple cancer-related signaling pathways, and represents a defense mechanis...
As seen in other types of cancer, development of drug resistance in NSCLC treatment causes adverse e...
Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion...
Oxidative stress created by environmental toxicants activates several signaling pathways. Autophagy ...
BACKGROUND AND PURPOSE Fangchinoline is a novel anti-tumour agent with little known of its cellular ...
Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional n...
Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional n...
Oxidative stress created by environmental toxicants activates several signaling pathways. Autophagy ...
<p>(A) Cell death of MDA-MB-231 cells treated with 6 uM of FAD with or without 100 uM of Z-VAD-fmk (...
Autophagy is a homeostatic process that is highly conserved across different types of mammalian cell...
Background: Breast cancer is accounted as the fifth leading cause of mortality among the other can-c...
Autophagy is a vital basic phenomenon that widely exists in eukaryotic cells. As one type of program...
Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer N H...
Autophagy is linked to multiple cancer-related signaling pathways, and represents a defense mechanis...
Autophagy is linked to multiple cancer-related signaling pathways, and represents a defense mechanis...
Autophagy is linked to multiple cancer-related signaling pathways, and represents a defense mechanis...
As seen in other types of cancer, development of drug resistance in NSCLC treatment causes adverse e...
Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion...
Oxidative stress created by environmental toxicants activates several signaling pathways. Autophagy ...
BACKGROUND AND PURPOSE Fangchinoline is a novel anti-tumour agent with little known of its cellular ...
Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional n...
Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional n...
Oxidative stress created by environmental toxicants activates several signaling pathways. Autophagy ...