In order to survive and cause disease, microbial pathogens must be able to proliferate at the temperature of their infected host. We identified novel microbial features associated with thermotolerance in the opportunistic fungal pathogen Cryptococcus neoformans using a random insertional mutagenesis strategy, screening for mutants with defective growth at 37°C. Among several thermosensitive mutants, we identified one bearing a disruption in a gene predicted to encode the Ape4 aspartyl aminopeptidase protein. Ape4 metalloproteases in other fungi, including Saccharomyces cerevisiae, are activated by nitrogen starvation, and they are required for autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway. However, none have been previously...
The opportunistic fungal pathogen Cryptococcus neoformans is a leading cause of mortality and morbid...
A library of more than 4,500 signature-tagged insertion mutants of the human pathogenic fungus Crypt...
International audienceIt is becoming increasingly obvious that glycophosphatidylinositol (GPI)-ancho...
<div><p>In order to survive and cause disease, microbial pathogens must be able to proliferate at th...
Fungal opportunistic pathogens colonize various environments, from plants and wood to human and anim...
AbstractFungal infections are often difficult to treat due to the inherent similarities between fung...
Cryptococcosis is an Invasive Fungal Infection (IFI) caused by Cryptococcus neoformans, mainly in im...
Cryptococcosis is an Invasive Fungal Infection (IFI) caused by Cryptococcus neoformans, mainly in im...
Autophagy is a mechanism responsible for intracellular degradation and recycling of macromolecules a...
Autophagy is a mechanism responsible for intracellular degradation and recycling of macromolecules a...
<div><p>Fungal opportunistic pathogens colonize various environments, from plants and wood to human ...
The opportunistic fungal pathogen Cryptococcus neoformans is a major cause of mortality in immunocom...
Fungal infections are often difficult to treat due to the inherent similarities between fungal and a...
Metabolic diversity is an important factor during microbial adaptation to different environments. Am...
Cryptococcus neoformans is an environmental basidiomycetous fungus and opportunistic pathogen that p...
The opportunistic fungal pathogen Cryptococcus neoformans is a leading cause of mortality and morbid...
A library of more than 4,500 signature-tagged insertion mutants of the human pathogenic fungus Crypt...
International audienceIt is becoming increasingly obvious that glycophosphatidylinositol (GPI)-ancho...
<div><p>In order to survive and cause disease, microbial pathogens must be able to proliferate at th...
Fungal opportunistic pathogens colonize various environments, from plants and wood to human and anim...
AbstractFungal infections are often difficult to treat due to the inherent similarities between fung...
Cryptococcosis is an Invasive Fungal Infection (IFI) caused by Cryptococcus neoformans, mainly in im...
Cryptococcosis is an Invasive Fungal Infection (IFI) caused by Cryptococcus neoformans, mainly in im...
Autophagy is a mechanism responsible for intracellular degradation and recycling of macromolecules a...
Autophagy is a mechanism responsible for intracellular degradation and recycling of macromolecules a...
<div><p>Fungal opportunistic pathogens colonize various environments, from plants and wood to human ...
The opportunistic fungal pathogen Cryptococcus neoformans is a major cause of mortality in immunocom...
Fungal infections are often difficult to treat due to the inherent similarities between fungal and a...
Metabolic diversity is an important factor during microbial adaptation to different environments. Am...
Cryptococcus neoformans is an environmental basidiomycetous fungus and opportunistic pathogen that p...
The opportunistic fungal pathogen Cryptococcus neoformans is a leading cause of mortality and morbid...
A library of more than 4,500 signature-tagged insertion mutants of the human pathogenic fungus Crypt...
International audienceIt is becoming increasingly obvious that glycophosphatidylinositol (GPI)-ancho...