Systemic corticosteroids have anti-inflammatory effects, whereas macrolides also have immunomodulatory activity in addition to their primary antimicrobial actions. We aimed to evaluate the potential interaction effect between corticosteroids and macrolides on the systemic inflammatory response in patients with severe community-acquired pneumonia to determine if combining these two immunomodulating agents was harmful, or possibly beneficial.We performed a post-hoc exploratory analysis of a randomized clinical trial conducted in three tertiary hospitals in Spain. This trial included patients with severe community-acquired pneumonia with high inflammatory response (C-reactive protein [CRP] >15 mg/dL) who were randomized to receive methylpredni...
The benefit of systemic steroids as adjunctive treatment in patients with severe community-acquired ...
Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acq...
International audienceBackground Some data suggest that anti-inflammatory macrolides may be effectiv...
Background: Systemic corticosteroids have anti-inflammatory effects, whereas macrolides also have im...
IMPORTANCE: In patients with severe community-acquired pneumonia, treatment failure is associated wi...
While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infec...
Objectives. While the inflammatory response to severe pneumonia is paramount in reining in and resol...
Antibiotic combinations that include macrolides have shown lower mortality rates than β-lactams in m...
ABSTRACT: The mortality rate in severe community- or hospital-acquired pneumonia is very high, rangi...
Background: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwi...
Introduction The benefit of corticosteroids as adjunctive treatment in patients with severe communit...
Community-acquired pneumonia (CAP) is a common disease with considerable morbidity and mortality, de...
Background. Macrolides are used to treat pneumonia despite increasing antimicrobial resistance. Howe...
ABSTRACT: The benefit of systemic steroids as adjunctive treatment in patients with severe community...
BACKGROUND Community-acquired pneumonia (CAP) is the third-leading infectious cause of death worl...
The benefit of systemic steroids as adjunctive treatment in patients with severe community-acquired ...
Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acq...
International audienceBackground Some data suggest that anti-inflammatory macrolides may be effectiv...
Background: Systemic corticosteroids have anti-inflammatory effects, whereas macrolides also have im...
IMPORTANCE: In patients with severe community-acquired pneumonia, treatment failure is associated wi...
While the inflammatory response to severe pneumonia is paramount in limiting and resolving the infec...
Objectives. While the inflammatory response to severe pneumonia is paramount in reining in and resol...
Antibiotic combinations that include macrolides have shown lower mortality rates than β-lactams in m...
ABSTRACT: The mortality rate in severe community- or hospital-acquired pneumonia is very high, rangi...
Background: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwi...
Introduction The benefit of corticosteroids as adjunctive treatment in patients with severe communit...
Community-acquired pneumonia (CAP) is a common disease with considerable morbidity and mortality, de...
Background. Macrolides are used to treat pneumonia despite increasing antimicrobial resistance. Howe...
ABSTRACT: The benefit of systemic steroids as adjunctive treatment in patients with severe community...
BACKGROUND Community-acquired pneumonia (CAP) is the third-leading infectious cause of death worl...
The benefit of systemic steroids as adjunctive treatment in patients with severe community-acquired ...
Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acq...
International audienceBackground Some data suggest that anti-inflammatory macrolides may be effectiv...