Genetic micro-epidemiology of malaria in Papua Indonesia: Extensive P. vivax diversity and a distinct subpopulation of asymptomatic P. falciparum infections.
- Zuleima Pava
- Rintis Noviyanti
- Irene Handayuni
- Hidayat Trimarsanto
- Leily Trianty
- Faustina H Burdam
- Enny Kenangalem
- Retno A S Utami
- Yusrifar K Tirta
- Farah Coutrier
- Jeanne R Poespoprodjo
- Ric N Price
- Jutta Marfurt
- Sarah Auburn
DOIAbstract
BACKGROUND:Genetic analyses of Plasmodium have potential to inform on transmission dynamics, but few studies have evaluated this on a local spatial scale. We used microsatellite genotyping to characterise the micro-epidemiology of P. vivax and P. falciparum diversity to inform malaria control strategies in Timika, Papua Indonesia. METHODS:Genotyping was undertaken on 713 sympatric P. falciparum and P. vivax isolates from a cross-sectional household survey and clinical studies conducted in Timika. Standard population genetic measures were applied, and the data was compared to published data from Kalimantan, Bangka, Sumba and West Timor. RESULTS:Higher diversity (HE = 0.847 vs 0.625; p = 0.017) and polyclonality (46.2% vs 16.5%, p<0.001) were...
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