Vps35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins. Dysfunction of retromer is a risk factor for the pathogenesis of Parkinson's disease (PD) and Alzheimer's disease (AD). However, Vps35/retromer's function in the eye or the contribution of Vps35-deficiency to eye degenerative disorders remains to be explored. Here we provide evidence for a critical role of Vps35 in mouse corneal dystrophy. Vps35 is expressed in mouse and human cornea. Mouse cornea from Vps35 heterozygotes (Vps35+/-) show features of dystrophy, such as loss of both endothelial and epithelial cell densities, disorganizations of endothelial, stroma, and epithelial cells, excresce...
The cornea is an anterior eye structure specialized for vision. The corneal endothelium and stroma a...
Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the r...
Pan X, Wang Y, Lübke T, Hinek A, Pshezhetsky AV. Mice, double deficient in lysosomal serine carboxyp...
<div><p>Vps35 (vacuolar protein sorting 35) is a major component of retromer that selectively promot...
PurposeTo elucidate the molecular events in solute carrier family 4 member 11 (SLC4A11)-deficient co...
Retromer is a protein assembly that plays a central role in orchestrating export of transmembrane-sp...
The vacuolar protein sorting 35 (VPS35) gene located on chromosome 16 has recently emerged as a caus...
SummaryRetromer is a protein assembly that plays a central role in orchestrating export of transmemb...
Vacuolar protein sorting 35 (VPS35) is a core component of the retromer trimer required for endosoma...
Vacuolar protein sorting 35 (VPS35) is a core component of the retromer complex, crucial to endosoma...
The PPCD1 mouse, a spontaneous mutant that arose in our mouse colony, is characterized by an enlarge...
Karlsson P, Droce A, Moser JM, et al. Loss of Vps54 Function Leads to Vesicle Traffic Impairment, Pr...
Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal transplantation. FECD...
<p>(A) Schematic showing the retromer complex associated with an endosomal membrane. Snx3 and Rab7A ...
The retromer complex is a highly conserved membrane trafficking assembly composed of three proteins ...
The cornea is an anterior eye structure specialized for vision. The corneal endothelium and stroma a...
Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the r...
Pan X, Wang Y, Lübke T, Hinek A, Pshezhetsky AV. Mice, double deficient in lysosomal serine carboxyp...
<div><p>Vps35 (vacuolar protein sorting 35) is a major component of retromer that selectively promot...
PurposeTo elucidate the molecular events in solute carrier family 4 member 11 (SLC4A11)-deficient co...
Retromer is a protein assembly that plays a central role in orchestrating export of transmembrane-sp...
The vacuolar protein sorting 35 (VPS35) gene located on chromosome 16 has recently emerged as a caus...
SummaryRetromer is a protein assembly that plays a central role in orchestrating export of transmemb...
Vacuolar protein sorting 35 (VPS35) is a core component of the retromer trimer required for endosoma...
Vacuolar protein sorting 35 (VPS35) is a core component of the retromer complex, crucial to endosoma...
The PPCD1 mouse, a spontaneous mutant that arose in our mouse colony, is characterized by an enlarge...
Karlsson P, Droce A, Moser JM, et al. Loss of Vps54 Function Leads to Vesicle Traffic Impairment, Pr...
Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal transplantation. FECD...
<p>(A) Schematic showing the retromer complex associated with an endosomal membrane. Snx3 and Rab7A ...
The retromer complex is a highly conserved membrane trafficking assembly composed of three proteins ...
The cornea is an anterior eye structure specialized for vision. The corneal endothelium and stroma a...
Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the r...
Pan X, Wang Y, Lübke T, Hinek A, Pshezhetsky AV. Mice, double deficient in lysosomal serine carboxyp...