To improve the safe use of allograft bone, decellularization techniques may be utilized to produce acellular scaffolds. Such scaffolds should retain their innate biological and biomechanical capacity and support mesenchymal stem cell (MSC) osteogenic differentiation. However, as allograft bone is derived from a wide age-range, this study aimed to determine whether donor age impacts on the ability an osteoinductive, acellular scaffold produced from human bone to promote the osteogenic differentiation of bone marrow MSCs (BM-MSC). BM-MSCs from young and old donors were seeded on acellular bone cubes from young and old donors undergoing osteoarthritis related hip surgery. All combinations resulted in increased osteogenic gene expression, and a...
The functional repair of large skeletal defects remains a significant challenge to orthopaedic surge...
Human adipose mesenchymal stem/stromal cells (Ad-MSCs) have been proposed as a suitable option for b...
At present, it is well known that populations of human bone marrow stromal cells (HBMSCs) can differ...
BACKGROUND AND PURPOSE: Age and co-morbidities compromise healing tendencies of traumatic fractures ...
Mesenchymal stromal cells (MSC) have been proposed as an emerging cell-based therapeutic option for ...
Abstract Background Human muscle-derived stem cells (hMDSCs) have been shown to regenerate bone effi...
UNLABELLED: Mesenchymal stem cells (MSC) are promising for cell-based regeneration therapies but up ...
Mesenchymal stem cells (MSCs) have great potential in tissue engineering as they can be easily isola...
Purpose: Human mesenchymal stem cells (MSCs) have the ability to differentiate into bone-forming ost...
The use of multipotent human mesenchymal stem cells (hMSCs) for tissue engineering has been a subjec...
Human adipose-derived mesenchymal stem cells (ASCs) transduced with a lentiviral vector system to ex...
BACKGROUND: The aim of this study was the investigation of the osteogenic potential of human osteobl...
[[abstract]]Many studies have indicated that loss of the osteoblastogenic potential in bone marrow m...
Treatment of a large bone defect is a difficult problem especially in modern aging society.Mesenchy...
Osteoporosis affects millions of people, and represents a substantial quality of life and economic b...
The functional repair of large skeletal defects remains a significant challenge to orthopaedic surge...
Human adipose mesenchymal stem/stromal cells (Ad-MSCs) have been proposed as a suitable option for b...
At present, it is well known that populations of human bone marrow stromal cells (HBMSCs) can differ...
BACKGROUND AND PURPOSE: Age and co-morbidities compromise healing tendencies of traumatic fractures ...
Mesenchymal stromal cells (MSC) have been proposed as an emerging cell-based therapeutic option for ...
Abstract Background Human muscle-derived stem cells (hMDSCs) have been shown to regenerate bone effi...
UNLABELLED: Mesenchymal stem cells (MSC) are promising for cell-based regeneration therapies but up ...
Mesenchymal stem cells (MSCs) have great potential in tissue engineering as they can be easily isola...
Purpose: Human mesenchymal stem cells (MSCs) have the ability to differentiate into bone-forming ost...
The use of multipotent human mesenchymal stem cells (hMSCs) for tissue engineering has been a subjec...
Human adipose-derived mesenchymal stem cells (ASCs) transduced with a lentiviral vector system to ex...
BACKGROUND: The aim of this study was the investigation of the osteogenic potential of human osteobl...
[[abstract]]Many studies have indicated that loss of the osteoblastogenic potential in bone marrow m...
Treatment of a large bone defect is a difficult problem especially in modern aging society.Mesenchy...
Osteoporosis affects millions of people, and represents a substantial quality of life and economic b...
The functional repair of large skeletal defects remains a significant challenge to orthopaedic surge...
Human adipose mesenchymal stem/stromal cells (Ad-MSCs) have been proposed as a suitable option for b...
At present, it is well known that populations of human bone marrow stromal cells (HBMSCs) can differ...