Effect of mycophenolate mofetil on the in vivo infiltration of lymphocytes in the rat remnant kidney.

THE DEVELOPMENT of progressive glomerulosclerosis in hyperfiltrating kidneys has been ascribed to a number of humoral and hemodynamic factors, including the upregulation of adhesion molecules and subsequent infiltration of leukocytes into the damaged tissue. Mycophenolate mofetil (MMF) is a new immunosuppressant that selectively inhibits the proliferation of lymphocytes and additionally downregulates the expression of adhesion molecules in vitro. In this study, we investigated the influence of a short-term pretreatment with MMF on the in vivo migration pattern of lymphocytes in a rat model of hyperfiltration