A novel neurological syndrome, mitochondrially inherited sensory ataxic neuropathy (SAN), was discovered in Golden Retriever dogs in Sweden. The purpose of the work described in the present thesis was to investigate the phenotype, clinical course and genotype of this syndrome by clinical, neurological and pathological examination of affected dogs, as well as to determine the mode of inheritance and identify the causative mutation. Mitochondrially inherited SAN in Golden Retriever dogs has an insidious onset during puppyhood. Affected dogs develop ataxia and dysmetria, with abnormal postural reactions and depressed spinal reflexes. The disease has a chronic, slowly progressive clinical course. Of the affected dogs investigated within the sco...
Background: The only hereditary neurologic disorder described so far in American Staffordshire Terri...
Spinocerebellar ataxias is an umbrella term for clinically- and neuropathologically-heterogeneous ea...
BACKGROUND Polioencephalopathies secondary to inborn errors of metabolism have been described in ...
A novel neurological syndrome, mitochondrially inherited sensory ataxic neuropathy (SAN), was discov...
Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in golden retrievers....
Introduction: Hereditary necrotizing myelopathy (HNM) in young Kooiker dogs is characterized by prog...
Understanding the genetic background of a given phenotypic trait or disease has long intrigued scien...
Introduction: Hereditary necrotizing myelopathy (HNM) in young Kooiker dogs is characterized by prog...
Dissertation supervisor: Dr. Gary S. Johnson.Includes vita.The genome of Canis lupus familiaris, the...
Hereditary neurological conditions documented in dogs encompass congenital, neonatal, and late-onset...
Canine degenerative myelopathy (DM) is a late-onset, progressive, neurodegenerative disorder with a ...
Author summary Hereditary ataxias, which are a group of disorders characterised by incoordination of...
Background: The only hereditary neurologic disorder described so far in American Staffordshire Terri...
Spinocerebellar ataxias is an umbrella term for clinically- and neuropathologically-heterogeneous ea...
BACKGROUND Polioencephalopathies secondary to inborn errors of metabolism have been described in ...
A novel neurological syndrome, mitochondrially inherited sensory ataxic neuropathy (SAN), was discov...
Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in golden retrievers....
Introduction: Hereditary necrotizing myelopathy (HNM) in young Kooiker dogs is characterized by prog...
Understanding the genetic background of a given phenotypic trait or disease has long intrigued scien...
Introduction: Hereditary necrotizing myelopathy (HNM) in young Kooiker dogs is characterized by prog...
Dissertation supervisor: Dr. Gary S. Johnson.Includes vita.The genome of Canis lupus familiaris, the...
Hereditary neurological conditions documented in dogs encompass congenital, neonatal, and late-onset...
Canine degenerative myelopathy (DM) is a late-onset, progressive, neurodegenerative disorder with a ...
Author summary Hereditary ataxias, which are a group of disorders characterised by incoordination of...
Background: The only hereditary neurologic disorder described so far in American Staffordshire Terri...
Spinocerebellar ataxias is an umbrella term for clinically- and neuropathologically-heterogeneous ea...
BACKGROUND Polioencephalopathies secondary to inborn errors of metabolism have been described in ...