In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, we designed and synthesized several polycyclic templates as potential substrates to be used in drug design. We obtained a set of condensed ring systems as versatile structural platforms to generate potential DNA-interactive agents and/or reversible inhibitors of enzymes such as topoisomerases, poly(ADPribose) polymerase-1 (PARP-1), telomerase, and, in particular, cyclin dependent kinases. Herein, we report the design, synthesis, structural investigation, and preliminary DNA-binding affinity of these heteroaromatic systems
Besides the well-known double-helical conformation, DNA is capable of folding into various noncanoni...
Boc-protected benzimidazole-pyrrole, benzimidazole-imidazole, and benzimidazole-methoxypyrrole amino...
The dictyodendrin alkaloids have been described as the first telomerase inhibitors of marine origin....
In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, we desi...
Previously, we designed and synthesized the 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione...
In this context, molecular recognition of DNA by polycyclic heterocycles having a planar structure ...
Higher-order DNA conformations can form within regions of DNA rich in guanines. Telomeric DNA, locat...
The synthesis and biological evaluation of a series of novel heterocyclic indole derivatives is desc...
The search for novel anti-infective and anticancer drugs ranges over many types of compound. Followi...
The title indolo-triazolo-pyrimidines were obtained from 3-azidoindoles and can be used as models fo...
[[abstract]]Utilizing scaffold-hopping drug-design strategy, we sought to identify a backup drug can...
New indolo- and pyrrolo-pyrimidines of type 1-4 were studied for their ability to form stable comple...
The design of new series of pyrrolo-pyrimidine derivatives, further annelated with a third heterocyc...
New classes of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors were studied in si...
We have synthesized and evaluated a series of hybrids, denoted 22--27, for in vitro cytotoxic activi...
Besides the well-known double-helical conformation, DNA is capable of folding into various noncanoni...
Boc-protected benzimidazole-pyrrole, benzimidazole-imidazole, and benzimidazole-methoxypyrrole amino...
The dictyodendrin alkaloids have been described as the first telomerase inhibitors of marine origin....
In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, we desi...
Previously, we designed and synthesized the 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione...
In this context, molecular recognition of DNA by polycyclic heterocycles having a planar structure ...
Higher-order DNA conformations can form within regions of DNA rich in guanines. Telomeric DNA, locat...
The synthesis and biological evaluation of a series of novel heterocyclic indole derivatives is desc...
The search for novel anti-infective and anticancer drugs ranges over many types of compound. Followi...
The title indolo-triazolo-pyrimidines were obtained from 3-azidoindoles and can be used as models fo...
[[abstract]]Utilizing scaffold-hopping drug-design strategy, we sought to identify a backup drug can...
New indolo- and pyrrolo-pyrimidines of type 1-4 were studied for their ability to form stable comple...
The design of new series of pyrrolo-pyrimidine derivatives, further annelated with a third heterocyc...
New classes of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors were studied in si...
We have synthesized and evaluated a series of hybrids, denoted 22--27, for in vitro cytotoxic activi...
Besides the well-known double-helical conformation, DNA is capable of folding into various noncanoni...
Boc-protected benzimidazole-pyrrole, benzimidazole-imidazole, and benzimidazole-methoxypyrrole amino...
The dictyodendrin alkaloids have been described as the first telomerase inhibitors of marine origin....