Cellular decision making in differentiation, proliferation or apoptosis is mediated by molecular signaling processes, which control the regulation and expression of genes. Vice versa, the expression of genes can trigger the activity of signaling pathways. I summarize methodology by Markowetz et al. known as the Nested Effects Models (NEMs) to reconstruct static non-transcriptional networks using subset relationships from perturbation data and bring out its limitation to model slow-going biological processes like cell differentiation. I introduce and describe new statistical methodologies called Dynamic Nested Effects Models (DNEMs) and Cyclic Dynamic Nested Effects Models (CDNEMs) for analyzing the temporal interplay of cell signaling and...
Complex cellular processes, such as phenotype decision making, are exceedingly difficult to analyze ...
Cell signaling is a complex process organized in time and space. Signal transduction is constantly m...
Strategies for rationally manipulating cell behavior in cell-based technologies and molecular therap...
Cellular decision making in differentiation, proliferation or apoptosis is mediated by molecular sig...
Cellular decision making in differentiation, proliferation, or cell death is mediated by molecular s...
La signalisation cellulaire regroupe l'ensemble des mécanismes biologiques permettant à une cellule ...
Cell signaling contains the whole biological mecanisms allowing the response of a cell to its microe...
Cellular signaling circuits handle an enormous range of computations. Beyond the housekeeping, repli...
Die Apoptose der Leberzellen ist abhängig von externen Signalen wie beispielsweise Komponenten der E...
Thousands of transcriptome data sets are available, but approaches for their use in dynamic cell res...
In the last few decades, extensive computational studies have been conducted on signaling pathways w...
Signaltransduction is an important process, that is crucial for the interplay of cells in multicellu...
Dynamic biological phenomena such as the development of immunity due to vaccination or the division ...
Cancer cells develop several hallmark changes over the progress of the tumor process. Cell assistanc...
Complex cellular processes, such as phenotype decision making, are exceedingly difficult to analyze ...
Cell signaling is a complex process organized in time and space. Signal transduction is constantly m...
Strategies for rationally manipulating cell behavior in cell-based technologies and molecular therap...
Cellular decision making in differentiation, proliferation or apoptosis is mediated by molecular sig...
Cellular decision making in differentiation, proliferation, or cell death is mediated by molecular s...
La signalisation cellulaire regroupe l'ensemble des mécanismes biologiques permettant à une cellule ...
Cell signaling contains the whole biological mecanisms allowing the response of a cell to its microe...
Cellular signaling circuits handle an enormous range of computations. Beyond the housekeeping, repli...
Die Apoptose der Leberzellen ist abhängig von externen Signalen wie beispielsweise Komponenten der E...
Thousands of transcriptome data sets are available, but approaches for their use in dynamic cell res...
In the last few decades, extensive computational studies have been conducted on signaling pathways w...
Signaltransduction is an important process, that is crucial for the interplay of cells in multicellu...
Dynamic biological phenomena such as the development of immunity due to vaccination or the division ...
Cancer cells develop several hallmark changes over the progress of the tumor process. Cell assistanc...
Complex cellular processes, such as phenotype decision making, are exceedingly difficult to analyze ...
Cell signaling is a complex process organized in time and space. Signal transduction is constantly m...
Strategies for rationally manipulating cell behavior in cell-based technologies and molecular therap...