Design, synthesis and structural evaluation of peptidomimetics with a defined secondary structure

The synthesis of new delta-amino acids based on a gamma-butyrolactone ring was performed and they were inserted into various peptidomimetics for conformational studies. Some non-substituted and substituted butyrolactone building blocks were prepared by various methods. Then, homopeptides as well as mixed peptides were prepared and their secondary structures analysed by various techniques including 2d-NMR, CD spectroscopy and IR in solution. In the second part of this project, some building blocks based on a diketopiperazine scaffold were prepared and inserted into homopolymers and cyclic peptidomimetics for secondary structure evaluation. In addition to these peptides, some potential organocatalysts containing the diketopiperazine scaffold were also prepared