Cα-Tetrasubstituted α-amino acids are important building blocks for the synthesis of peptidemimetics with stabilized secondary structure, because of their ability to rigidify the peptide backbone. Recently our group reported a new class of cyclic Cα-tetrasubstituted tetrahydrofuran α-amino acids prepared from methionine and aromatic aldehydes. We now report the extension of this methodology to aliphatic aldehydes. Although such aldehydes are prone to give aldol products under the reaction conditions used, we were able to obtain the target cyclic amino acids in low to moderate yields and in some cases with good diastereoselectivity
Copyright © 2004 American Chemical SocietyHere we report a versatile ring-closing metathesis-based a...
An improved second-generation synthesis of the unnatural amino acid components of the anticancer pep...
A protected aldehyde was attached via a twocarbon spacer to a peptide backbone amide nitrogen during...
This thesis is concerned with the synthesis of β-amino-acid peptides. The linear tripeptide of β-ala...
We report a new methodology for the synthesis of chiral nonproteinaceous alpha-amino acids, which in...
A new and convenient method for the synthesis and incorporation of N(alpha)-(1-phenyl-2-mercaptoethy...
This thesis describes the synthesis of a family of amino acids containing a ketone functionalised si...
The synthesis of a series of novel alpha-amino acids based on the nucleophilic substitution of prote...
The synthesis of tetrahydrofuran C(alpha)-tetrasubstituted amino acids (TAAs) and their effect on th...
The synthesis of α/β dipeptides containing linear or cyclic α-dehydro-β-amino acids has been perform...
In 1908, H. Emil Fisher attempted to prepare glycinal, an unprotected amino aldehyde, which he found...
The synthesis of libraries of conformationally constrained peptide-like oligomers is an important go...
Methods of synthesis of peptides incorporating sterically hindered alpha-amino acids, such as C-alp...
â-Amino acids-based peptides have gained much attention in synthetic community forthe last few deca...
The benzylidene derivative of glycine ethyl ester was alkylated with various electrophiles to synthe...
Copyright © 2004 American Chemical SocietyHere we report a versatile ring-closing metathesis-based a...
An improved second-generation synthesis of the unnatural amino acid components of the anticancer pep...
A protected aldehyde was attached via a twocarbon spacer to a peptide backbone amide nitrogen during...
This thesis is concerned with the synthesis of β-amino-acid peptides. The linear tripeptide of β-ala...
We report a new methodology for the synthesis of chiral nonproteinaceous alpha-amino acids, which in...
A new and convenient method for the synthesis and incorporation of N(alpha)-(1-phenyl-2-mercaptoethy...
This thesis describes the synthesis of a family of amino acids containing a ketone functionalised si...
The synthesis of a series of novel alpha-amino acids based on the nucleophilic substitution of prote...
The synthesis of tetrahydrofuran C(alpha)-tetrasubstituted amino acids (TAAs) and their effect on th...
The synthesis of α/β dipeptides containing linear or cyclic α-dehydro-β-amino acids has been perform...
In 1908, H. Emil Fisher attempted to prepare glycinal, an unprotected amino aldehyde, which he found...
The synthesis of libraries of conformationally constrained peptide-like oligomers is an important go...
Methods of synthesis of peptides incorporating sterically hindered alpha-amino acids, such as C-alp...
â-Amino acids-based peptides have gained much attention in synthetic community forthe last few deca...
The benzylidene derivative of glycine ethyl ester was alkylated with various electrophiles to synthe...
Copyright © 2004 American Chemical SocietyHere we report a versatile ring-closing metathesis-based a...
An improved second-generation synthesis of the unnatural amino acid components of the anticancer pep...
A protected aldehyde was attached via a twocarbon spacer to a peptide backbone amide nitrogen during...