A hydrogen peroxide sensor for exhaled breath measurement

An increase in produced hydrogen peroxide concentration in exhaled breath (EB) of patients, who suffer from some diseases related to lung function, has been observed and considered as a reliable indicator of lung diseases. In the EB of these patients, hydrogen peroxide is present in the vapour phase together with water, thus one of the approaches of monitoring hydrogen peroxide in the EB is to condense it and then to perform the hydrogen peroxide measurement in the condensate. Earlier, a hydrogen peroxide sensor based on an Electrolyte Metal Oxide Semiconductor Field-Effect Transistor, EMOSFET, has been investigated. The sensor shows the possibility to measure hydrogen peroxide at a concentration of micro-molar level. Due to its miniaturizability, the sensor is able to detect hydrogen peroxide in a small solution volume, especially suitable for monitoring of hydrogen peroxide in the EB. In this paper, a new setup for condensation hydrogen peroxide in the EB is introduced. The setup consists of a cooling part using a Peltier cooler for condensation of the exhaled breath air and the EMOSFET based hydrogen peroxide sensor. Preliminary results on the collection and measurement of hydrogen peroxide in artificial EB are given