Among the cellular properties that are essential for the organization of tissues during animal development, the importance of cell polarity in the plane of epithelial sheets has become increasingly clear in the past decades. Planar cell polarity (PCP) signaling in vertebrates has indispensable roles in many aspects of their development, in particular, controlling alignment of various types of epithelial cells. Disrupted PCP has been linked to developmental defects in animals and to human pathology. Neural tube closure defects (NTD) and disorganization of the mechanosensory cells of the organ of Corti are commonly known consequences of disturbed PCP signaling in mammals. We report here a typical PCP phenotype in a mouse mutant for the Sec24b...
The planar cell polarity (PCP) pathway is a conserved non-canonical (β-catenin-independent) branch o...
Environmental and genetic aberrations lead to neural tube closure defects (NTDs) in 1 out of every 1...
Neural tube closure is a critical developmental event that provides an extraordinary example of how ...
Among the cellular properties that are essential for the organization of tissues during animal devel...
Craniorachischisis is a rare but severe birth defect that results in a completely open neural tube. ...
Anterograde transport in eukaryotic cells begins at the endoplasmic reticulum (ER), where cargo prot...
Neural tube defects (NTDs) are among the commonest and most severe forms of developmental defect, ch...
Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished ...
AbstractThe coordinated polarization of neighboring cells within the plane of the tissue, known as p...
In the nervous system, cilia dysfunction perturbs the circulationof the cerebrospinal fluid, thus af...
Abstract Neural tube defects (NTDs) are the second most common birth defect in humans. Despite many ...
The role of planar cell polarity (PCP) signalling in neural crest (NC) development is unclear. The P...
Neural tube defects (NTDs) are a heterogeneous group of common severe congenital anomalies which aff...
Background The planar cell polarity (PCP) signalling pathway is fundamental to a number of key devel...
SummaryProteins trafficking through the secretory pathway must first exit the endoplasmic reticulum ...
The planar cell polarity (PCP) pathway is a conserved non-canonical (β-catenin-independent) branch o...
Environmental and genetic aberrations lead to neural tube closure defects (NTDs) in 1 out of every 1...
Neural tube closure is a critical developmental event that provides an extraordinary example of how ...
Among the cellular properties that are essential for the organization of tissues during animal devel...
Craniorachischisis is a rare but severe birth defect that results in a completely open neural tube. ...
Anterograde transport in eukaryotic cells begins at the endoplasmic reticulum (ER), where cargo prot...
Neural tube defects (NTDs) are among the commonest and most severe forms of developmental defect, ch...
Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished ...
AbstractThe coordinated polarization of neighboring cells within the plane of the tissue, known as p...
In the nervous system, cilia dysfunction perturbs the circulationof the cerebrospinal fluid, thus af...
Abstract Neural tube defects (NTDs) are the second most common birth defect in humans. Despite many ...
The role of planar cell polarity (PCP) signalling in neural crest (NC) development is unclear. The P...
Neural tube defects (NTDs) are a heterogeneous group of common severe congenital anomalies which aff...
Background The planar cell polarity (PCP) signalling pathway is fundamental to a number of key devel...
SummaryProteins trafficking through the secretory pathway must first exit the endoplasmic reticulum ...
The planar cell polarity (PCP) pathway is a conserved non-canonical (β-catenin-independent) branch o...
Environmental and genetic aberrations lead to neural tube closure defects (NTDs) in 1 out of every 1...
Neural tube closure is a critical developmental event that provides an extraordinary example of how ...