Determinants of change in airway reactivity over 11 years in the SAPALDIA population study
- Curjuric, I
- Zemp, E
- Dratva, J
- Ackermann-Liebrich, U
- Bridevaux, P-O
- Bettschart, R W
- Brutsche, M
- Frey, M
- Gerbase, M W
- Knöpfli, B
- Künzli, N
- Pons, M
- Schwartz, J
- Schindler, C
- Rochat, T
DOIAbstract
We investigated determinants of change in bronchial reactivity in the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA), a population-based cohort with wide age range (29-72 yrs at follow-up). The role of sex, age, atopic status, smoking and body mass index (BMI) on percentage change in bronchial reactivity slope from the baseline value was analysed in 3,005 participants with methacholine tests in 1991 and 2002, and complete covariate data. Slope was defined as percentage decline in forced expiratory volume in 1 s from its maximal value per micromole of methacholine. Bronchial hyperreactivity prevalence fell from 14.3 to 12.5% during follow-up. Baseline age was nonlinearly associated with change in reactivity slope:...
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