Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000
- Möricke, A
- Zimmermann, M
- Reiter, A
- Henze, G
- Schrauder, A
- Gadner, H
- Ludwig, W D
- Ritter, J
- Harbott, J
- Mann, G
- Klingebiel, T
- Zintl, F
- Niemeyer, C
- Kremens, B
- Niggli, F
- Niethammer, D
- Welte, K
- Stanulla, M
- Odenwald, E
- Riehm, H
- Schrappe, M
DOIAbstract
Between 1981 and 2000, 6609 children (<18 years of age) were treated in five consecutive trials of the Berlin-Frankfurt-Münster (BFM) study group for childhood acute lymphoblastic leukemia (ALL). Patients were treated in up to 82 centers in Germany, Austria and Switzerland. Probability of 10-year event-free survival (EFS) (survival) improved from 65% (77%) in study ALL-BFM 81 to 78% (85%) in ALL-BFM 95. In parallel to relapse reduction, major efforts focused on reducing acute and late toxicity through advanced risk adaptation of treatment. The major findings derived from these ALL-BFM trials were as follows: (1) preventive cranial radiotherapy could be safely reduced to 12 Gy in T-ALL and high-risk (HR) ALL patients, and eliminated in non- ...
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