Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both during and after treatment cessation. To assess the responses to irradiation and vascular endothelial growth factor-receptor tyrosine kinase inhibition (by the vascular endothelial growth factor tyrosine kinase inhibitor PTK787/ZK222854), mammary carcinoma allografts were investigated by vascular casting; electron, light, and confocal microscopy; and immunoblotting. Irradiation and anti-angiogenic therapy had similar effects on the tumor vasculature. Both treatments reduced tumor vascularization, particularly in the tumor medulla. After cessation of therapy, the tumor vasculature expanded predominantly by intussusception with a plexus composed...
Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mecha...
Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer....
Emerging preclinical studies support the concept of a transient "normalization" of tumor vasculature...
Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both d...
Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both d...
BACKGROUND: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are nat...
Angiogenesis supplies oxygen and nutrients to growing tumors. Inhibiting angiogenesis may stop tumor...
AbstractProteolytic fragments of various components of the extracellular matrix exhibit antiangiogen...
Although cancer cells are not generally controlled by normal regulatory mechanisms, tumor growth is ...
Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However,...
Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6t...
The final proof of principle that cancer patients can be effectively treated with angiogenesis inhib...
It remains controversial whether targeting tumour vasculature can improve radiotherapeutic efficacy....
Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2005.Includes bibliographic...
Intussusception (growth within itself) is an alternative to the sprouting mode of angiogenesis. The ...
Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mecha...
Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer....
Emerging preclinical studies support the concept of a transient "normalization" of tumor vasculature...
Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both d...
Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both d...
BACKGROUND: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are nat...
Angiogenesis supplies oxygen and nutrients to growing tumors. Inhibiting angiogenesis may stop tumor...
AbstractProteolytic fragments of various components of the extracellular matrix exhibit antiangiogen...
Although cancer cells are not generally controlled by normal regulatory mechanisms, tumor growth is ...
Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However,...
Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6t...
The final proof of principle that cancer patients can be effectively treated with angiogenesis inhib...
It remains controversial whether targeting tumour vasculature can improve radiotherapeutic efficacy....
Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2005.Includes bibliographic...
Intussusception (growth within itself) is an alternative to the sprouting mode of angiogenesis. The ...
Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mecha...
Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer....
Emerging preclinical studies support the concept of a transient "normalization" of tumor vasculature...