Stable polymorphs crystallized directly under thermodynamic control in three-dimensional nanoconfinement : a generic methodology.

Thermodynamic control of crystallization has been achieved to produce stable polymorphs directly by using three-dimensional (3D) nanoconfinement in microemulsions. The theoretical basis for thermodynamic control of crystallization using 3D nanoconfinement is outlined. The generality of our approach is demonstrated by crystallizing the stable polymorph of three “problem” compounds from microemulsions under conditions yielding metastable forms in bulk solution