This thesis investigates artificial agents learning to make strategic decisions in imperfect-information games. In particular, we introduce a novel approach to reinforcement learning from self-play. We introduce Smooth UCT, which combines the game-theoretic notion of fictitious play with Monte Carlo Tree Search (MCTS). Smooth UCT outperformed a classic MCTS method in several imperfect-information poker games and won three silver medals in the 2014 Annual Computer Poker Competition. We develop Extensive-Form Fictitious Play (XFP) that is entirely implemented in sequential strategies, thus extending this prominent game-theoretic model of learning to sequential games. XFP provides a principled foundation for self-play reinforcement learning in...