Microvascular and endothelial dysfunction in the pathophysiology of disease progression in dengue: an observational study in Vietnam
- Yacoub, Sophie
DOIAbstract
Dengue infection can present with a broad spectrum of clinical phenotypes. The hallmark of severe disease is increased vascular permeability, sometimes leading to hypovolaemic shock. Microvascular/ endothelial dysfunction may underlie this, but have not been assessed clinically. I performed a prospective observational study in two hospitals in Vietnam recruiting 300 children (> 3 years) and adults presenting to a) outpatient department with fever for <72 hours and suspected dengue, b) patients hospitalized with warning signs or severe disease. Clinical and laboratory assessments were performed daily for 5 days, and 2 weeks later. Microvascular imaging using Sidestream dark field Imaging (SDF), and endothelial function testing using periph...
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