Duchenne muscular dystrophy is the most prevalent and severe of the muscular dystrophies. A hallmark of dystrophic muscle is fibrosis which is a result of chronic cycles of degeneration and regeneration. Cardiac fibrosis interferes with contractility and rhythm of the heart and cardiomyopathy is a leading cause of mortality in DMD. While gene therapy may offer a cure in the future, there exists an immediate need to ameliorate the symptoms of DMD. The mdx mouse is the most widely used animal model in DMD research. The initial study of this dissertation examined cardiac parameters of the mdx mouse at different ages (3, 6 and 12 months) and found a progressive cardiac involvement. Compromised systolic and diastolic function was evident from...
Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (D...
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder caused by loss of dystroph...
Duchenne and Becker muscular dystrophies (DMD/BMD) result in progressive weakness of skeletal and ca...
Duchenne muscular dystrophy is the most prevalent and severe of the muscular dystrophies. A hallmark...
Duchenne Muscular Dystrophy (DMD) is a fatal condition occurring in approximately 1 in 3500 male bir...
Aims The mdx mouse has proven to be useful in understanding the cardiomyopathy that frequently occu...
Duchenne muscular dystrophy (DMD) is a fatal X-linked disease affecting 1 in 3500 live male births t...
PhD ThesisDuchenne Muscular Dystrophy (DMD) is an X-linked disorder, caused by mutations in the DMD...
We evaluated the effects of long-term administration of de-flazacort (DFZ) on the progression of myo...
The majority of patients afflicted with Duchenne muscular dystrophy develop cardiomyopathic complic...
Background: Fibrosis, an excessive collagen accumulation, results in scar formation, impairing funct...
Duchenne muscular dystrophy (DMD) is a genetically inherited debilitating muscle disorder affecting ...
The extracellular matrix (ECM) of the skeletal muscle provides the framework for the muscle structur...
Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive mu...
Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (D...
Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (D...
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder caused by loss of dystroph...
Duchenne and Becker muscular dystrophies (DMD/BMD) result in progressive weakness of skeletal and ca...
Duchenne muscular dystrophy is the most prevalent and severe of the muscular dystrophies. A hallmark...
Duchenne Muscular Dystrophy (DMD) is a fatal condition occurring in approximately 1 in 3500 male bir...
Aims The mdx mouse has proven to be useful in understanding the cardiomyopathy that frequently occu...
Duchenne muscular dystrophy (DMD) is a fatal X-linked disease affecting 1 in 3500 live male births t...
PhD ThesisDuchenne Muscular Dystrophy (DMD) is an X-linked disorder, caused by mutations in the DMD...
We evaluated the effects of long-term administration of de-flazacort (DFZ) on the progression of myo...
The majority of patients afflicted with Duchenne muscular dystrophy develop cardiomyopathic complic...
Background: Fibrosis, an excessive collagen accumulation, results in scar formation, impairing funct...
Duchenne muscular dystrophy (DMD) is a genetically inherited debilitating muscle disorder affecting ...
The extracellular matrix (ECM) of the skeletal muscle provides the framework for the muscle structur...
Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive mu...
Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (D...
Various therapeutic approaches have been studied for the treatment of Duchenne muscular dystrophy (D...
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder caused by loss of dystroph...
Duchenne and Becker muscular dystrophies (DMD/BMD) result in progressive weakness of skeletal and ca...