In Vivo Proton MR Spectroscopy Reveals Altered Metabolite Content in Malignant Prostate Tissue

Abstract. Background: Recently the potential o f magnetic guided biopsies) have been of limited value for diagnosis and resonance (MR) methods for non-invasive diagnosis and therapy evaluation o f prostate cancer has improved substantially, In this study proton MR spectroscopy (lH MRS) was explored for the detection o f cancer in the prostate, Patients and Methods: Employing an endorectal probe localized JH MRS and contrast therapy evaluation of prostate cancer [2], Also MR imaging (MRI) is of little use to detect PCa and to determine its extent, although the more recent introduction of endorectal and body phased-array radiofrequency detection coils have enabled better staging of PCa [3,4>5]. The potential of MR enhanced MR imaging was performed on the prostate o f healthy may be further improved by the use of more adva nced volunteers and o f patients with benign prostatic hyperplasia (BPH) and/or prostate cancer (PCa). Results:!H MR spectra o f the human prostate showed major signals for citrate, creatin