Add to ORKGCD22, a regulator of B-cell signaling, is a siglec that rec-ognizes the sequence NeuAc2–6Gal on glycoprotein gly-cans as ligands. CD22 interactions with glycoproteins on the same cell (in cis) and apposing cells (in trans) modu-late its activity in B-cell receptor signaling. Although CD22 predominantly recognizes neighboring CD22 molecules as cis ligands on B-cells, little is known about the trans ligands on apposing cells. We conducted a proteomics scale study to identify candidate trans ligands of CD22 on B-cells by UV photocross-linking CD22-Fc chimera bound to B-cell glycoproteins engineered to carry sialic acids with a 9-aryl azide moiety. Using mass spectrometry-based quantitative proteomics to analyze the cross-linked products, 27 gl...
A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory r...
The B lymphocyte cell surface receptor CD22 is an adhesion molecule that can mediate binding to seve...
CD22 and Siglec-G are members of the Siglec family. Both are inhibitory co-receptors on the surface ...
CD22, a regulator of B-cell signaling, is a siglec that rec-ognizes the sequence NeuAc2–6Gal on glyc...
An important inhibitory co-receptor on B-cells is CD22, a sialic-acid binding protein. CD22 is highl...
CD22 beta is a glycoprotein found on the surface of B cells during restricted stages of development....
CD22 is a B cell lineage restricted cell-surface adhesion glycoprotein which recognizes ligands on h...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
CD22 is a member of the sialic acid-binding Ig-like lectin (Siglec) family that is known to be a reg...
The B-cell receptor CD22 binds sialic acid linked alpha-2-6 to terminal galactose residues on N-link...
A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory r...
The B lymphocyte cell surface receptor CD22 is an adhesion molecule that can mediate binding to seve...
CD22 and Siglec-G are members of the Siglec family. Both are inhibitory co-receptors on the surface ...
CD22, a regulator of B-cell signaling, is a siglec that rec-ognizes the sequence NeuAc2–6Gal on glyc...
An important inhibitory co-receptor on B-cells is CD22, a sialic-acid binding protein. CD22 is highl...
CD22 beta is a glycoprotein found on the surface of B cells during restricted stages of development....
CD22 is a B cell lineage restricted cell-surface adhesion glycoprotein which recognizes ligands on h...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
The organization and clustering of cell surface proteins plays a critical role in controlling recept...
CD22 is a member of the sialic acid-binding Ig-like lectin (Siglec) family that is known to be a reg...
The B-cell receptor CD22 binds sialic acid linked alpha-2-6 to terminal galactose residues on N-link...
A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory r...
The B lymphocyte cell surface receptor CD22 is an adhesion molecule that can mediate binding to seve...
CD22 and Siglec-G are members of the Siglec family. Both are inhibitory co-receptors on the surface ...