Add to ORKGLocked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression
Background: Modified nucleotides are increasingly being utilized in the de novo selection of aptamer...
LNA nucleoside 5’-triphosphates have been investigated as substrates for various DNA and RNA polymer...
Among numerous nucleic acid analogs reported in the past decades, locked nucleic acid (LNA) has rece...
Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinit...
Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excelle...
Double-stranded oligodeoxynucleotides (ODN) containing the consensus binding sequence of a transcrip...
AbstractLocked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methyl...
Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phen...
DNA is the genetic code of life, containing vital information required for the existence of life. An...
Nucleic acid–based therapeutic technologies (Figure 9.1) have significantly advanced in the past two...
The use of PNAs in therapeutics is limited by its mechanism of action. PNA (peptide nucleic acid) ac...
Conventional drugs target proteins while oligonucleotide (ON) drugs can target mRNA, which is presen...
The available reagents for the attachment of func-tional moieties to plasmid DNA are limiting. Most ...
Nucleic acid therapy comprises several approaches based on nucleic acid as the active therapeutic co...
This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first descr...
Background: Modified nucleotides are increasingly being utilized in the de novo selection of aptamer...
LNA nucleoside 5’-triphosphates have been investigated as substrates for various DNA and RNA polymer...
Among numerous nucleic acid analogs reported in the past decades, locked nucleic acid (LNA) has rece...
Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinit...
Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excelle...
Double-stranded oligodeoxynucleotides (ODN) containing the consensus binding sequence of a transcrip...
AbstractLocked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methyl...
Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phen...
DNA is the genetic code of life, containing vital information required for the existence of life. An...
Nucleic acid–based therapeutic technologies (Figure 9.1) have significantly advanced in the past two...
The use of PNAs in therapeutics is limited by its mechanism of action. PNA (peptide nucleic acid) ac...
Conventional drugs target proteins while oligonucleotide (ON) drugs can target mRNA, which is presen...
The available reagents for the attachment of func-tional moieties to plasmid DNA are limiting. Most ...
Nucleic acid therapy comprises several approaches based on nucleic acid as the active therapeutic co...
This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first descr...
Background: Modified nucleotides are increasingly being utilized in the de novo selection of aptamer...
LNA nucleoside 5’-triphosphates have been investigated as substrates for various DNA and RNA polymer...
Among numerous nucleic acid analogs reported in the past decades, locked nucleic acid (LNA) has rece...