Nitrosamine-Induced Adenocarcinoma in

ABSTRACT-A pancreatic ductal carcinoma, designated CBP, was established as a transplantable tumor line in the CB/SsLak inbred strain of Syrian golden hamsters. The tumor, a primary one induced by chronic administration of the nitrosamine N-nitro-bis(2-hydroxypropyl)amine, is a well-differentiated adeno-carcinoma that can be propagated by transplantation in syn-geneic hamsters. It grows poorly in other hamster strains. The CBP tumor develops in a predictable quantitative manner and metastasizes to regional lymph nodes. Excision of primary trans-planted tumor nodules leads to immunity against subsequent secondary tumor challenges. The CBP tumor appears to be a suitable model for biologic and immunologic studies of pan-creatic carcinoma in the Syrian hamster.-JNCI 1981; 67:1093-1100. Pancreatic carcinoma represents a clinical proble