The effect of hyperthermia on vascular function, pH, and cell survival," Radiology

ABSTRACT-The effect of hyperthermia on vascular volume and vascular permeability of the Walker carcinoma 256, skin, and muscle of Inbred SD male rats was Investigated. Wh,,.reas heating at 43 ° C for 1 hour Induced a significant Increase In the functional vascular volume and vascular permeability In the skin and mus-cle, It did not change these vascular functions In the tumors. The Increased vascular volume In the normal tissues suggested an Increased circulation, which may enhance the dissipation of heat and result In a differential effect of hype'rthermla on normal tissues and tumors.-J Natl Cancer Inst 60: 711-713, 1978. Interest in the use of hyperthermia as a primary modality or in combination with radiotherapy for treat-ment of malignant disease has been renewed recently (1-8). Radiotherapists are particularly interested in hy-perthermia because of abundant evidence that hyper