Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective. There is also increasing concern about their use in children. Environmental irritants such as air pollution and cigarette smoke are thought to evoke cough by stimulating airway sensory nerves; however, how this occurs is not fully understood. Objectives: We hypothesized that the TRPA1 (transient receptor potential cation channel, subfamily A, member 1) receptor may have a role as a novel target for tussive agents given that many potential irritants have been shown to activate this channel. Methods: We inves...
AbstractTransient receptor potential vanilloid type channels (TRPVs) are expressed in several cell t...
The TRPV4 channel is a member of the Transient Receptor Potential family of ion channels and is know...
Cough is an important protective reflex. Sensory nerve activity mediating cough may be enhanced duri...
Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a genera...
Cough is under the control of sensory afferents which innervate the airways via the vagus nerve. Co...
International audienceThe cough reflex becomes hyperresponsive in acute and chronic respiratory dise...
Cough is a protective reflex action that helps clear the respiratory tract which is continuously exp...
Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel is expressed abundantly on the C fibers t...
Cough is a protective reflex action that helps clear the respiratory tract which is continuously exp...
Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicate...
TRPA1 is a cation channel of the transient receptor potential channel family that is predominantly e...
Cough is the most common reason for patients to visit a primary care physician, yet it remains an un...
AbstractCough is a protective reflex and defence mechanism in healthy individuals, which helps clear...
Transient receptor potential (TRP) A1 and TRPM8 are ion channels that have been localized to afferen...
BackgroundSensory nerves innervating the airways play an important role in regulating various cardio...
AbstractTransient receptor potential vanilloid type channels (TRPVs) are expressed in several cell t...
The TRPV4 channel is a member of the Transient Receptor Potential family of ion channels and is know...
Cough is an important protective reflex. Sensory nerve activity mediating cough may be enhanced duri...
Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a genera...
Cough is under the control of sensory afferents which innervate the airways via the vagus nerve. Co...
International audienceThe cough reflex becomes hyperresponsive in acute and chronic respiratory dise...
Cough is a protective reflex action that helps clear the respiratory tract which is continuously exp...
Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel is expressed abundantly on the C fibers t...
Cough is a protective reflex action that helps clear the respiratory tract which is continuously exp...
Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicate...
TRPA1 is a cation channel of the transient receptor potential channel family that is predominantly e...
Cough is the most common reason for patients to visit a primary care physician, yet it remains an un...
AbstractCough is a protective reflex and defence mechanism in healthy individuals, which helps clear...
Transient receptor potential (TRP) A1 and TRPM8 are ion channels that have been localized to afferen...
BackgroundSensory nerves innervating the airways play an important role in regulating various cardio...
AbstractTransient receptor potential vanilloid type channels (TRPVs) are expressed in several cell t...
The TRPV4 channel is a member of the Transient Receptor Potential family of ion channels and is know...
Cough is an important protective reflex. Sensory nerve activity mediating cough may be enhanced duri...